An Overview of X-Linked Hypophosphatemia

X-linked dominant inheritance
scenarios for either the mother or father being affected By File:Autosomal dominant - en.svg: Domaina,
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A resident of Los Angeles, Dr. Mark Paskewitz is the vice president of the National Institute of Clinical Research, Inc., and the former senior director of clinical development at Kyowa Kirin Pharma, Inc. In his role as senior director, Dr. Mark Paskewitz worked on the development of the first drug approved to treat X-linked hypophosphatemia (XLH), a genetic disease that affects the bones.

XLH is an inherited disease that is usually detected in childhood and characterized by low blood levels of phosphate as a result of the abnormal processing of phosphate in the kidneys. An increased rate of phosphate loss in the urine leads to weakened, soft bones throughout the body. Those affected by this condition may have bone and joint pain, short stature, bowed legs, and severe dental pain. However, the severity of the disease varies significantly, as some people with the condition may have ongoing pain and complications, while others have minimal symptoms.

Treatment for XLH typically involves supplementing with high doses of the active form of vitamin D and phosphate. Corrective surgery, dental treatment, and taking growth hormones may also be necessary for treating XLH.

Norman Stone’s “Europe Transformed" Explores Roots of Protectionism

John Stuart Mill
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In his role as vice president of the National Institute of Clinical Research, Inc., Mark Paskewitz focuses on developing innovative pharmaceutical products. A history enthusiast, Mark Paskewitz enjoys learning about past events that shaped Europe into what it is today.

One concept with particular current resonance is that of “synchronous political waves.” This was explored by British historian Norman Stone in his seminal 1983 work Europe Transformed 1878-1919. Stone examines the decline of a 19th century Europe defined by liberalism, in which England promoted a free trade stream that brought an end to protectionist measures across Europe, as items such as passports briefly went by the wayside.

With John Stuart Mill a leading philosophical guidepost, the Victorian ideal of the 1860s was one in which government interference was kept to a minimum and people placed checks on their own actions. Unfortunately, at the apex of liberalism’s triumph, the system started to destroy itself. This was due in large part to an unexpected impact of increased economic integration: negative, as well as positive, trends that tended to impact all European nations at the same time.

This was particularly felt during the Panic of 1873, which left government revenues depleted and gave rise to calls for more activist state intervention in the world economy. Sacrificed in the resulting rivalries that emerged was free trade, as high-tariff policies were instituted that insulated domestic workers from competition and sowed the seeds of discord between nations that erupted in two world wars.

Arcangelo Corelli - Virtuoso Violist and Composer Who Defined Baroque

Musical notes
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Mark Paskewitz is an executive with the National Institute of Clinical Research, Inc., who focuses on developing next-generation drugs. A classical music aficionado, Mark Paskewitz particularly enjoys the works of Mozart, as well as Baroque composers such as Tomaso Albinoni and Arcangelo Corelli.

Original from Bologna, Corelli was active in Rome in the late 17th and early 18th centuries, and was a major force behind what emerged as the modern conception of orchestral playing.

With Cardinal Ottoboni, Pope Alexander VIII’s nephew, as his patron, he set in place a directive that all string players should bow in the same direction, at the same time, which brought unprecedented accuracy to orchestral playing.

Corelli was also one of the era’s leading violinists. A particular innovation was in introducing the technique of playing more than one note within a single bow stroke, as well as double- and triple-stopping, or playing two to three notes at the same time. In addition to teaching pupils such as Locatelli and Geminiani, his style directly influenced composers who emerged slightly later than him, such as Vivaldi, Handel, and Bach.

Successful both as a musician and concertmaster, Corelli amassed a large fortune during his lifetime, and was buried in Rome’s Pantheon. He left behind a significant collection of art that included works by Poussin and Bruegel.

The Career of Impressionistic Painter Auguste Renoir

Paintbrushes and paints
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Dr. Mark Paskewitz is the vice president of clinical operations for the National Institute of Clinical Research in Los Angeles. In addition to his work, Dr. Mark Paskewitz enjoys the paintings of artists such as Auguste Renoir.

Pierre-Auguste Renoir (better known simply as Auguste Renoir) was born in Limoges, France, in 1841. In his teens in Paris, he found work painting decorative vases and plates from templates. As he learned other forms of painting he became a student of the sculptor Louis-Denis Caillouette.

Renoir learned his craft by copying artworks in the Louvre and was admitted to the prestigious Ecole des Beaux-Arts. At the school he met other students, such as Paul Cezanne, Claude Monet, and Camille Pissaro. Though he struggled to make ends meet at this time, Renoir, his friends, and another artist, Edgar Degas, presented a show in 1874.

A critic described their work as “impressions,” as opposed to conventionally finished works. The name stuck. Renoir’s work did not bring him financial success, but it did inspire the support of several patrons. Attracted by his bright colors and unique brushstrokes, the public gradually made him famous.

The artist’s favorite subjects were his growing family, as well as scenes at home and in the country. However, the physical labor of painting drained him as he dealt with rheumatism until his death in 1919.

In addition to influencing such greats as Pablo Picasso and Henri Matisse, Renoir left a living legacy. His son Jean was a filmmaker who was named the 12th-best movie director of all time - and the best in France - by Entertainment Weekly.

Spain’s Modernist Architecture During the Franco Years

Streets of Madrid

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Mark Paskewitz is a longtime National Institute of Clinical Research, Inc., executive who has guided clinical development efforts for groundbreaking drugs. An avid follower of current events, Mark Paskewitz regularly reads up on news of Spain in the country’s original language. 

A recent article in the Guardian highlighted the persistent legacy of Spain’s longtime dictator Francisco Franco in the country’s contemporary culture. One of the unique aspect of the regime (which was tragic to many in other respects) was its tolerance of a wide variety of architecture. 

In addition to his imperialist ambitions, Franco considered himself an artist and embraced modernism in architecture. The striking 1949 creation of the Basilica at Arantzazu in the Basque Country represented a collaboration between architect Francisco Javier Sáenz de Oiza and sculptor Jorge Oteiza. The religious structure broke radically from papal design traditions, to the point where it was seen as a snub of Rome.

Much of the country’s architecture looked outward as fascist Spain entered a period of strategic alliance with the United States. Building styles were influenced by the technocratic Opus Dei, a lay Catholic organization, and Miguel Fisac’s Pagoda in the suburbs of Madrid is a striking example of the country’s full turn toward modernism. Demolished in 1999, the building combined raw concrete and horizontal windows in an assemblage of stacked triangular shapes, evoking the Asian pagoda. Another noteworthy concrete creation of the era was de Oiza’s Torres Blancas building, which had the visual effect of odd geometric mushrooms.

Spain Drives Eurozone Growth in First Quarter

Streets of Spain
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Clinical research executive Mark Paskewitz has an interest in international affairs. By reading news sources based in Europe, Mark Paskewitz stays informed on current events in the French- and Spanish-speaking world.

For the past five years, the Spanish economy has grown steadily. In early 2019, the southern European nation led the Eurozone in growth, with a rate of 2.5 percent.

Some drivers of the Spanish economy include tourism and green energy infrastructure. Tourism made up nearly 15 percent of Spain’s gross domestic product, and the sector is expected to grow by 2.8 percent this year.

Further, the government has pledged nearly 50 billion euros into the green energy sector in an attempt to reach carbon neutrality within 30 years. Spain also sold more than 120 billion euros in bonds to Japanese investors. While this remarkable growth helped add more than 300,000 jobs, Spain still struggles with a high unemployment rate, which hovers at 14 percent.

Spain Breaks into Top 5 on HSBC Best Countries for Expats List

Banking professional
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Outside of his work in clinical research, Los Angeles resident Mark Paskewitz is dedicated to improving his language ability in French and Spanish. Mark Paskewitz practices his Spanish by reading articles from Spain-based news outlets and staying informed of current events in the country.

In the latest survey of foreign workers conducted by multinational bank HSBC, Spain ranked in the top five countries for expats for the first time. Spain beat out other popular destinations such as New Zealand, the United Arab Emirates, and Germany. 

The survey scores livability based on living standards, work-life balance, and career opportunities. Spain secured its spot due to high rankings in the areas of quality of life and benefits for families. Respondents also lauded the relaxed culture and stunning weather as major highlights. 

However, the country’s low salaries and limited job market landed it in 22nd place for career advancement. Foreigners in Spain earn around 50 percent less than the average expat.